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Pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin and biotin.

作者信息

Rosebrough S F

机构信息

Department of Radiology, University of Rochester Medical Center, NY 14642.

出版信息

Nucl Med Biol. 1993 Jul;20(5):663-8. doi: 10.1016/0969-8051(93)90037-u.

DOI:10.1016/0969-8051(93)90037-u
PMID:8358353
Abstract

The extraordinary high affinity of avidin and streptavidin for biotin may be exploited in a two-step approach for delivering radiolabeled biotin derivatives suitable for imaging and therapy to target-bound streptavidin or avidin conjugated monoclonal antibodies (MAbs). The in vivo pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin (SA) and DTPA-biocytinamide (DTPA-biotin) were studied in the rabbit and dog. SA circulated in the blood similar to other 60 kDa proteins, avidin cleared immediately and DTPA-biotin exhibited plasma clearance by glomerular filtration.

摘要

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