McCarthy T J, Dence C S, Welch M J
Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110.
Appl Radiat Isot. 1993 Aug;44(8):1129-32. doi: 10.1016/0969-8043(93)90118-t.
A modified synthesis of [18F]fluoromisonidazole is reported which makes use of microwave heating to reduce the synthesis time to ca 70 min from EOB. A remote system for column purification, concentration and delivery to an HPLC syringe, which reduces the total absorbed dose to the operator, is also described.
报道了一种[18F]氟米索硝唑的改进合成方法，该方法利用微波加热将合成时间从EOB缩短至约70分钟。还描述了一种用于柱纯化、浓缩并输送至HPLC注射器的远程系统，该系统可降低操作人员的总吸收剂量。
