外周内毒素可诱导大鼠下丘脑产生免疫反应性白细胞介素-1β 。
Peripheral endotoxin induces hypothalamic immunoreactive interleukin-1 beta in the rat.
作者信息
Hillhouse E W, Mosley K
机构信息
Department of Clinical Biochemistry, School of Biomedical and Biomolecular Sciences, University of Newcastle, Newcastle upon Tyne.
出版信息
Br J Pharmacol. 1993 Jun;109(2):289-90. doi: 10.1111/j.1476-5381.1993.tb13567.x.
Abstract
Interleukin-1 (IL-1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL-1 beta in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL-1 beta (IL-1 beta) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL-1 beta.
摘要
白细胞介素-1（IL-1）是一种由多种细胞产生的多肽，它参与机体对炎症的整体反应。它具有广泛的炎症、代谢、生理、造血和免疫活性。包括神经元、小胶质细胞、内皮细胞和星形胶质细胞在内的脑细胞，在受到各种生理和病理刺激时均能产生IL-1β。在本报告中，我们发现通过一种针对大鼠IL-1β的超灵敏、高度特异性酶放大免疫测定法检测，外周给予内毒素可刺激大鼠下丘脑出现免疫反应性IL-1β（IL-1β）。
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