A68是印第安纳家族型格斯特曼-施特劳斯勒-谢inker病成对螺旋丝的一个组成部分。
A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
作者信息
Tagliavini F, Giaccone G, Prelli F, Verga L, Porro M, Trojanowski J Q, Farlow M R, Frangione B, Ghetti B, Bugiani O
机构信息
Istituto Neurologico Carlo Besta, Milano, Italy.
出版信息
Brain Res. 1993 Jul 9;616(1-2):325-9. doi: 10.1016/0006-8993(93)90226-d.
Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated the composition of PHF in this family by immunocytochemistry and immunoblot analysis. The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's disease, and suggest that post-translational modifications of tau leading to formation of A68 are not unique to Alzheimer's disease.
印第安纳家族中的格斯特曼-施特劳斯勒-申克病在病理上的特征是朊蛋白淀粉样沉积物以及带有双螺旋丝（PHF）的神经原纤维缠结（NFT）。我们使用针对tau分子不同结构域的抗体，通过免疫细胞化学和免疫印迹分析研究了该家族中PHF的组成。结果表明，A68是该家族NFT的一个组成部分，就如同在阿尔茨海默病中一样，这表明导致A68形成的tau蛋白翻译后修饰并非阿尔茨海默病所特有。
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