白细胞和亚硝酸盐尿试纸条在神经源性膀胱患儿管理中的应用。

Application of a leukocyte and nitrite urine test strip to the management of children with neurogenic bladder.

作者信息

Anderson J D, Chambers G K, Johnson H W

机构信息

Department of Pathology, University of British Columbia, BC's Children's Hospital, Vancouver, Canada.

出版信息

Diagn Microbiol Infect Dis. 1993 Jul;17(1):29-33. doi: 10.1016/0732-8893(93)90066-g.

DOI:10.1016/0732-8893(93)90066-g

PMID:8359003

Abstract

A urine leukocyte count of > or = 50/mm3 together with a bacterial count of > or = 10(5) colony-forming units (CFUs) per milliliter was used to define significant infection in 160 children with neurogenic bladder and evaluate the leukocyte and nitrite components of the Chemstrip 9 test. A Chemstrip 9 leukocyte reading of < or = 25 together with a negative nitrite reaction occurred in 99 children and had a sensitivity of 83.5% and a negative predictive value for infection of 97.0%. A Chemstrip 9 reading of > or = 500 leukocytes together with a positive nitrite reaction occurred in 18 children and had a sensitivity of 40% with a 100% positive predictive value for infection. Other combinations of Chemstrip 9 leukocyte and nitrite reactions were unhelpful or of uncertain value. Selection of up to three specimens from each patient increased the number of samples to 360 and provided general confirmation of the above conclusions. Nitrofurantoin may reduce the sensitivity of the nitrite strip reaction.

摘要

对于160名神经源性膀胱患儿，尿白细胞计数≥50/mm³且细菌计数≥10⁵菌落形成单位（CFU）/毫升被用于定义严重感染，并评估Chemstrip 9检测的白细胞和亚硝酸盐成分。99名患儿的Chemstrip 9白细胞读数≤25且亚硝酸盐反应为阴性，其敏感性为83.5%，感染的阴性预测值为97.0%。18名患儿的Chemstrip 9白细胞读数≥500且亚硝酸盐反应为阳性，其敏感性为40%，感染的阳性预测值为100%。Chemstrip 9白细胞和亚硝酸盐反应的其他组合无帮助或价值不确定。从每位患者最多选取三个标本，样本数量增加到360个，并总体证实了上述结论。呋喃妥因可能会降低亚硝酸盐试纸反应的敏感性。