CP-99433与其他氟喹诺酮类药物相比的体外抗菌活性。

In vitro antimicrobial activity of CP-99433 compared with other fluoroquinolones.

作者信息

Johnson D M, Jones R N, Erwin M E

机构信息

Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.

出版信息

Diagn Microbiol Infect Dis. 1993 Jul;17(1):79-83. doi: 10.1016/0732-8893(93)90076-j.

DOI:10.1016/0732-8893(93)90076-j

PMID:8359012

Abstract

CP-99433 is a new C-7 diazabicyclofluoroquinolone with a broad spectrum of activity that includes Enterobacteriaceae, Gram-positive cocci, and nonenteric Gram-negative bacilli. Potent activity was demonstrated against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC90, 0.5 microgram/ml), Xanthomonas maltophilia (MIC90, 1 microgram/ml), and all Streptococcus species (MIC90s, 0.25-1 microgram/ml). Only CP-99433 was active against Enterococcus faecium (MIC50, 2 micrograms/ml). CP-99433 also demonstrated activity against several ciprofloxacin-resistant staphylococci. Additional studies of CP-99433 activity appear indicated.

摘要

CP - 99433是一种新型的C - 7二氮杂双环氟喹诺酮类药物，具有广泛的活性，包括肠杆菌科细菌、革兰氏阳性球菌和非肠道革兰氏阴性杆菌。对铜绿假单胞菌[最低抑菌浓度（MIC90，0.5微克/毫升）]、嗜麦芽窄食单胞菌（MIC90，1微克/毫升）以及所有链球菌属菌种（MIC90，0.25 - 1微克/毫升）均显示出强效活性。只有CP - 99433对粪肠球菌有活性（MIC50，2微克/毫升）。CP - 99433对几种耐环丙沙星的葡萄球菌也显示出活性。似乎有必要对CP - 99433的活性进行更多研究。