甲状腺素运载蛋白的表达在肝脏中比在大脑中进化得更晚。

Transthyretin expression evolved more recently in liver than in brain.

Schreiber G, Pettersson T M, Southwell B R, Aldred A R, Harms P J, Richardson S J, Wettenhall R E, Duan W, Nicol S C

Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Australia.

Comp Biochem Physiol B. 1993 Jun;105(2):317-25. doi: 10.1016/0305-0491(93)90235-w.

Abstract

Transthyretin was found to be synthesized and secreted by choroid plexus from rats, echidnas, and lizards, but not toads. 2. Transthyretin was observed in blood from placental mammals, birds, and marsupials, but not reptiles and monotremes. 3. The obtained data suggest that transthyretin synthesis by the liver evolved independently in the lineage leading to the placental mammals and marsupials and in that leading to the birds. 4. It is proposed that transthyretin gene expression in mammalian liver appeared about 200 million years later than its first occurrence in the choroid plexus of the stem reptiles.

摘要

研究发现，转甲状腺素蛋白由大鼠、针鼹和蜥蜴的脉络丛合成并分泌，但蟾蜍的脉络丛不分泌。2. 在胎盘哺乳动物、鸟类和有袋动物的血液中观察到转甲状腺素蛋白，但爬行动物和单孔目动物的血液中未观察到。3. 所得数据表明，肝脏中转甲状腺素蛋白的合成在导致胎盘哺乳动物和有袋动物的谱系以及导致鸟类的谱系中是独立进化的。4. 有人提出，哺乳动物肝脏中转甲状腺素蛋白基因的表达比其在原始爬行动物脉络丛中的首次出现晚约2亿年。