Blardi P, Laghi Pasini F, Urso R, Frigerio C, Volpi L, De Giorgi L, Di Perri T
Istituto di Clinica Medica, Università di Siena, Italy.
Eur J Clin Pharmacol. 1993;44(5):505-7. doi: 10.1007/BF00315554.
The plasma kinetics of adenosine was investigated in healthy volunteers after a 1 minute infusion of 2.5, 5 and 10 mg (38.79 and 148 micrograms.kg-1 respectively) and after infusion of 200 micrograms.kg-1 in 10 min followed by 400 micrograms.kg-1 in 10 min. As the dose in the 1 min infusion study was increased the mean CL of adenosine decreased (10.7, 4.70 and 4.14 l.min-1, respectively), its mean half-life increased (0.91, 1.24 and 1.86 min, respectively), and the mean volume of distribution did not show any clear trend (8-13 l). After the 20 minute infusion the plasma level of adenosine reached a peak value comparable to that observed after infusion of 5 mg in 1 min (about 0.5 micrograms.ml-1), but the mean clearance and half-life were significantly different (12.1 l.min-1 and 0.63 min respectively). In all the subjects the plasma concentration of adenosine had returned to the baseline value in 5-15 min after the end of the infusion.
在健康志愿者中，研究了分别以2.5毫克、5毫克和10毫克（分别为38.79和148微克·千克⁻¹）静脉输注1分钟后，以及先以200微克·千克⁻¹静脉输注10分钟、再以400微克·千克⁻¹静脉输注10分钟后腺苷的血浆动力学。在1分钟输注研究中，随着剂量增加，腺苷的平均清除率降低（分别为10.7、4.70和4.14升·分钟⁻¹），平均半衰期延长（分别为0.91、1.24和1.86分钟），平均分布容积未呈现明显趋势（8 - 13升）。在20分钟输注后，腺苷的血浆水平达到的峰值与1分钟输注5毫克后观察到的峰值相当（约0.5微克·毫升⁻¹），但平均清除率和半衰期显著不同（分别为12.1升·分钟⁻¹和0.63分钟）。在所有受试者中，输注结束后5 - 15分钟内，腺苷的血浆浓度均恢复至基线值。
