三氟拉嗪对胰岛素诱导的骨骼肌葡萄糖摄取增加的抑制作用。

Trifluoperazine inhibition of insulin-induced increase in skeletal muscle glucose uptake.

作者信息

Guarner V, Hernández E H, Huerto R, Gorostiza P, Valenzuela F

机构信息

Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.

出版信息

Eur J Pharmacol. 1993 Jun 11;237(1):139-41. doi: 10.1016/0014-2999(93)90103-o.

DOI:10.1016/0014-2999(93)90103-o

PMID:8359207

Abstract

The ability of trifluoperazine, a calmodulin blocker, to prevent increases in skeletal muscle glucose uptake induced by insulin was tested. Insulin significantly increased glucose uptake by the rat hindlimb and trifluoperazine (10(-6) M) completely inhibited this increase. We conclude that calmodulin is a factor involved in the regulation of insulin-mediated glucose transport in muscle cells.

摘要

测试了钙调蛋白阻滞剂三氟拉嗪阻止胰岛素诱导的骨骼肌葡萄糖摄取增加的能力。胰岛素显著增加了大鼠后肢的葡萄糖摄取，而三氟拉嗪（10^(-6) M）完全抑制了这种增加。我们得出结论，钙调蛋白是参与调节肌肉细胞中胰岛素介导的葡萄糖转运的一个因素。