van Laarhoven C J, Borstlap A C, van Berge Henegouwen D P, Palmen F M, Verpalen M C, Schoemaker M C
Department of Surgery, St Elisabeth Hospital, Tilburg, The Netherlands.
Eur J Vasc Surg. 1993 Jul;7(4):386-90. doi: 10.1016/s0950-821x(05)80254-3.
In a prospective study during the period January-May 1992, 362 consecutive out-patients above 65 years of age, attending the pulmonary department for chronic obstructive airways disease (COPD), were ultrasonographically screened for an aneurysm of the abdominal aorta (AAA). Data from pulmonary function tests together with history of cardiac disease, diabetes mellitus, hypertension, hypercholesterolaemia, peripheral arterial obstructive disease, smoking and corticosteroid medication were collected. 30/282 men and 6/80 women with COPD had an AAA > or = 30 mm in diameter, which equals a prevalence of 9.9% (95% confidence limits: 6.8-13.0%). COPD patients with severe emphysema, having a decreased forced expiratory volume/vital capacity ratio (FEV/VC) of < 55%, have a significantly higher prevalence of aortic dilatation or AAA compared to COPD patients with mild or moderate decreased FEV/VC (chi-squared test: p < 0.05, alpha = 0.05). In the group of patients with AAA, significantly more smokers were seen compared to the group with normal and dilated aortas (chi-squared test: p < 0.05).
在1992年1月至5月期间进行的一项前瞻性研究中,对362名连续就诊于肺部疾病科的65岁以上慢性阻塞性气道疾病(COPD)门诊患者进行了腹部主动脉瘤(AAA)的超声筛查。收集了肺功能测试数据以及心脏病、糖尿病、高血压、高胆固醇血症、外周动脉阻塞性疾病、吸烟和使用皮质类固醇药物的病史。282名男性和80名女性COPD患者中,分别有30名和6名患者的AAA直径≥30 mm,患病率为9.9%(95%置信区间:6.8 - 13.0%)。与FEV/VC轻度或中度降低的COPD患者相比,FEV/VC降低至<55%的重度肺气肿COPD患者主动脉扩张或AAA的患病率显著更高(卡方检验:p < 0.05,α = 0.05)。与主动脉正常和扩张的患者组相比,AAA患者组中吸烟者明显更多(卡方检验:p < 0.05)。