Kitajima T, Yamaguchi T, Tani K, Kubota Y, Okuhira M, Inoue K, Yamada H
Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Digestion. 1993;54(3):156-9. doi: 10.1159/000201030.
The current study was designed to investigate the role of two potent vasoactive substances, endothelin (ET) and platelet-activating factor (PAF), in the pathogenesis of indomethacin-induced gastric lesions in rats. Treatment with anti-ET antibody before indomethacin administration resulted in a significant decline in the total length of the lesions as determined by gross evaluation. In contrast, CV-6209, a specific PAF antagonist, had no effect on the total length of the lesions. The results strongly suggest the incorporation of endogenous ET in the mechanism of gastric damage after indomethacin administration.
本研究旨在探讨两种强效血管活性物质，即内皮素（ET）和血小板活化因子（PAF）在吲哚美辛诱导的大鼠胃损伤发病机制中的作用。在给予吲哚美辛之前用抗ET抗体治疗，通过大体评估确定损伤的总长度显著下降。相比之下，特异性PAF拮抗剂CV-6209对损伤的总长度没有影响。结果强烈提示内源性ET参与了吲哚美辛给药后胃损伤的机制。
