Wołczyński S, Kulikowski M, Szamatowicz M
Zakładu Endokrynologii Ginekologicznej, Instytutu Połoznictwa i Chorób Kobiecych w Białymstoku.
Ginekol Pol. 1993 Mar;64(3):154-60.
Triploidy is a frequent chromosomal abnormality found in 12% of all spontaneous first trimester abortions. Triploidy can result from various mechanisms: failure of segregation during meiosis I or II leads to the formation of gametes with an extra haploid set of chromosomes or abnormally fertilization by two spermatozoa. The authors presents physiological mechanism which prevent polyspermic fertilization, the morphological pictures of triploid early embryos. After implantation of triploid embryos partial embryonal hydatidiform moles develops. Now the possibility of the prevention and treatment of triploid in humans are very limited.
三倍体是一种常见的染色体异常,在所有孕早期自然流产中占12%。三倍体可由多种机制导致:减数分裂I或II期间的分离失败会导致形成具有额外单倍体染色体组的配子,或由两个精子异常受精。作者介绍了防止多精受精的生理机制、三倍体早期胚胎的形态学图片。三倍体胚胎着床后会发展为部分胚胎性葡萄胎。目前,人类三倍体的预防和治疗可能性非常有限。