Nienhuis H E, Rongen-Westerlaken C, Wit J M, Otten B J, de Muinck Keizer-Schrama S M, Drayer N M, Delemarre-van de Waal H A, Vulsma T, Oostdijk W, Waelkens J J
Department of Paediatrics, University of Utrecth, The Netherlands.
Horm Res. 1993;39 Suppl 2:31-6. doi: 10.1159/000182765.
Girls with Turner syndrome were divided according to age (group A 6-12 years, and group B 12-19 years) and human growth hormone (GH) dose regimen (A1 and B1, three injections/week; A2 and B2, six injections/week). All groups responded to GH, 24 IU/m2/week, with an increase in height velocity, though in the older girls, the response was comparatively poor. Therefore, the dose regimens in groups B1 and B2 were increased to 36 IU/m2/week given as six injections in both groups. This change resulted in an increase in height velocity only in group B1. During the first 2 years only, the height velocity was greater in group A2 than group A1. The conclusion is that a regimen of six injections/week is more effective than one of three injections/week in terms of initial height gain and change in predicted adult height. In girls with Turner syndrome aged over 16 years, GH therapy has no significant effect.
患有特纳综合征的女孩根据年龄（A组6至12岁，B组12至19岁）和人生长激素（GH）剂量方案（A1和B1，每周注射三次；A2和B2，每周注射六次）进行分组。所有组对24 IU/m²/周的GH治疗均有反应，身高增长速度加快，不过年龄较大的女孩反应相对较差。因此，B1组和B2组的剂量方案增加至36 IU/m²/周，两组均为每周注射六次。这一改变仅使B1组的身高增长速度加快。仅在最初2年，A2组的身高增长速度高于A1组。结论是，就初始身高增长和预测成人身高变化而言，每周注射六次的方案比每周注射三次的方案更有效。对于16岁以上的特纳综合征女孩，GH治疗无显著效果。
