Mahaboob Basha P
Department of Zoology, Bangalore University, India.
Indian J Exp Biol. 1993 Apr;31(4):369-72.
Sublethal doses of methyl parathion (o, o-dimethyl-o-nitrophenyl thiophosphate) injected intraperitoneally to 7th day old developing albino rat pups induced alterations in the inhibitory GABAergic system of CNS. A substantial simulation of the inhibitory system was noticed. A profound increase was found in the level of the inhibitory transmitter, GABA on methyl parathion injection. An increase in the activity levels of the enzymes glutamic acid decarboxylase and 4-aminobutyrate-2-oxoglutarate-amino transferase in the cortex, brain stem and spinal cord of the CNS was found. It is observed that methyl parathion causes potentiation of the inhibitory transmission (GABAergic system) in the wake of inducing suppression of cholinergic system in CNS of developing rat pups.
向7日龄发育中的白化大鼠幼崽腹腔注射亚致死剂量的甲基对硫磷（o，o-二甲基-o-硝基苯基硫代磷酸酯）会引起中枢神经系统抑制性γ-氨基丁酸能系统的改变。观察到抑制系统有显著的模拟现象。注射甲基对硫磷后，抑制性神经递质γ-氨基丁酸的水平大幅升高。在中枢神经系统的皮质、脑干和脊髓中，发现谷氨酸脱羧酶和4-氨基丁酸-2-氧代戊二酸氨基转移酶的活性水平有所增加。据观察，在发育中的大鼠幼崽中枢神经系统中，甲基对硫磷在诱导胆碱能系统抑制后会导致抑制性传递（γ-氨基丁酸能系统）增强。
