替曲菲班，一种新型纤维蛋白原受体拮抗剂。II. 结构解析。

Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation.

作者信息

Kamiyama T, Itezono Y, Umino T, Satoh T, Nakayama N, Yokose K

机构信息

Nippon Roche Research Center, Kanagawa, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jul;46(7):1047-54. doi: 10.7164/antibiotics.46.1047.

DOI:10.7164/antibiotics.46.1047

PMID:8360098

Abstract

The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.

摘要

从新泻链霉菌NR0577培养液中分离出的新型强效纤维蛋白原受体拮抗剂四纤维蛋白的结构已确定。四纤维蛋白具有独特的结构，包含伯胺、共轭四烯酸和多羟基官能团，在生物合成上与多烯大环内酯类抗生素相关。