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R1128物质，一种由链霉菌产生的新型非甾体雌激素受体拮抗剂。II. 物理化学性质及结构测定

R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination.

作者信息

Hori Y, Takase S, Shigematsu N, Goto T, Okuhara M, Kohsaka M

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jul;46(7):1063-8. doi: 10.7164/antibiotics.46.1063.

DOI:10.7164/antibiotics.46.1063
PMID:8360100
Abstract

R1128 A, B, C and D, new non-steroidal estrogen-receptor antagonists, were isolated from the cultured broth of Streptomyces sp. No. 1128. Their structures were elucidated to be 1,3,6-trihydroxy-8-alkylanthraquinones on the basis of their physico-chemical properties and spectroscopic data.

摘要

R1128 A、B、C和D是新型非甾体雌激素受体拮抗剂，从链霉菌属1128号菌株的培养液中分离得到。根据其物理化学性质和光谱数据，确定它们的结构为1,3,6-三羟基-8-烷基蒽醌。

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