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Chemical modification of erythromycins. XII. A facile synthesis of clarithromycin (6-O-methylerythromycin A) via 2'-silylethers of erythromycin A derivatives.

作者信息

Watanabe Y, Adachi T, Asaka T, Kashimura M, Matsunaga T, Morimoto S

机构信息

Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jul;46(7):1163-7. doi: 10.7164/antibiotics.46.1163.

DOI:10.7164/antibiotics.46.1163
PMID:8360112
Abstract
摘要

相似文献

1
Chemical modification of erythromycins. XII. A facile synthesis of clarithromycin (6-O-methylerythromycin A) via 2'-silylethers of erythromycin A derivatives.
J Antibiot (Tokyo). 1993 Jul;46(7):1163-7. doi: 10.7164/antibiotics.46.1163.
2
Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin.
J Antibiot (Tokyo). 1993 Apr;46(4):647-60. doi: 10.7164/antibiotics.46.647.
3
Chemical modification of erythromycins. II. Synthesis and antibacterial activity of O-alkyl derivatives of erythromycin A.
J Antibiot (Tokyo). 1990 Mar;43(3):286-94. doi: 10.7164/antibiotics.43.286.
4
Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.
J Antibiot (Tokyo). 1990 May;43(5):544-9. doi: 10.7164/antibiotics.43.544.
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Microbial transformation of 6-O-methylerythromycin derivatives.
J Antibiot (Tokyo). 1988 Jul;41(7):908-15. doi: 10.7164/antibiotics.41.908.
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Synthesis and antibacterial activities of novel 12-O-methylerythromycin A derivatives.新型12-O-甲基红霉素A衍生物的合成及其抗菌活性
J Antibiot (Tokyo). 1999 Oct;52(10):908-12. doi: 10.7164/antibiotics.52.908.
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Synthesis and biological investigation of new 4''-malonyl tethered derivatives of erythromycin and clarithromycin.
Bioorg Med Chem Lett. 2006 Mar 15;16(6):1506-9. doi: 10.1016/j.bmcl.2005.12.033. Epub 2006 Jan 4.
8
14-Hydroxy-6-O-methylerythromycins A, active metabolites of 6-O-methylerythromycin A in human.
J Antibiot (Tokyo). 1988 Jul;41(7):966-75. doi: 10.7164/antibiotics.41.966.
9
Chemical modification of erythromycins. III. In vitro and in vivo antibacterial activities of new semisynthetic 6-O-methylerythromycins A, TE-031 (clarithromycin) and TE-032.
J Antibiot (Tokyo). 1990 Mar;43(3):295-305. doi: 10.7164/antibiotics.43.295.
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Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A.红霉素的化学修饰。I. 6-O-甲基红霉素A的合成及抗菌活性
J Antibiot (Tokyo). 1984 Feb;37(2):187-9. doi: 10.7164/antibiotics.37.187.

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