Sudbury A W, Marinopoulos J, Gunn P
Department of Mathematics, Monash University, Clayton, Victoria, Australia.
J Forensic Sci Soc. 1993 Apr-Jun;33(2):73-82. doi: 10.1016/s0015-7368(93)72984-9.
DNA profiling allows determination of the alleles at multiple loci on an individual's genome. The frequencies of these alleles are then estimated from a sample drawn from the population. If the occurrences of alleles at different loci are independent, the frequencies may be multiplied together to give an estimate of the probability of DNA from a randomly-chosen member of the population matching the DNA in question. However, there is doubt as to whether the assumption of independence can be justified. This paper discusses a method of calculating the probability of a match that does not require the assumption of independence. A suitable set of criteria is also derived that offer an objective approach to the determination of a match from two DNA samples.
DNA 图谱分析能够确定个体基因组中多个位点的等位基因。然后，通过从人群中抽取的样本估计这些等位基因的频率。如果不同位点上等位基因的出现是相互独立的，那么这些频率可以相乘，以估计从人群中随机选择的个体的 DNA 与所讨论的 DNA 匹配的概率。然而，独立性假设是否合理存在疑问。本文讨论了一种计算匹配概率的方法，该方法不需要独立性假设。还推导了一组合适的标准，为从两个 DNA 样本中确定匹配提供了一种客观方法。
