Gondo K, Miyachi H, Tanaka Y, Kawada T, Kato S, Arimori S, Ando Y
Central Clinical Laboratory, Tokai University Hospital.
Rinsho Ketsueki. 1993 Jul;34(7):835-41.
The mean platelet volume (MPV) was measured in 14 patients with acute leukemia during the course of chemotherapy for remission induction and 21 patients undergoing bone marrow transplantation, in order to assess its usefulness as an indicator for megakaryothrombopoiesis at bone marrow suppression and recovery. In patients with acute leukemia, the MPV fell from 9.7 +/- 0.8 fl to 9.2 +/- 0.4 fl during the myelosuppression, and then it rose transiently to 10.2 +/- 0.5 fl and fell to 9.3 +/- 0.5 fl during recovery of platelet count. Similarly, in patients undergoing bone marrow transplantation, the MPV elevation was followed by the recovery of platelet count. Thus, when engraftment was defined as this MPV elevation, engraftment was confirmed significantly earlier by MPV (19.9 +/- 5.8 days) than by platelet count (24.8 +/- 6.7 days). MPV should be a useful indicator for engraftment or recovery from marrow aplasia in cases of acute leukemia and those of bone marrow transplantation.
为评估平均血小板体积（MPV）作为骨髓抑制和恢复时巨核细胞血小板生成指标的效用，对14例急性白血病患者在诱导缓解化疗期间及21例接受骨髓移植的患者进行了MPV测定。急性白血病患者中，骨髓抑制期间MPV从9.7±0.8飞升至9.2±0.4飞升，随后在血小板计数恢复期间短暂升至10.2±0.5飞，然后降至9.3±0.5飞。同样，在接受骨髓移植的患者中，MPV升高后血小板计数恢复。因此，当将植入定义为MPV升高时，通过MPV确认植入（19.9±5.8天）明显早于通过血小板计数（24.8±6.7天）。在急性白血病和骨髓移植病例中，MPV应是植入或从骨髓再生障碍恢复的有用指标。
