Smith J, Kelly K A, Weinshilboum R M
Arch Surg. 1977 Feb;112(2):203-9. doi: 10.1001/archsurg.1977.01370020097011.
In eight dogs, cellotomy, rubbing the small bowel, and exposing it to air suppressed the migrating bursts of action potentials and contractions that occur in the gastrointestinal tract during fasting and greatly slowed (one to three days) the gastrointestinal transit of 7-mm plastic spheres. The operation also caused a transient one-day increase in the concentration of epinephrine and a more prolonged five-day increase in the concentration and norepinephrine in arterial and venous plasma. Phentolamine mesylate and propranolol hydrochloride prevented the inhibition of the bursts of gastric action potentials brought about by operation, but these drugs did not alter the inhibition of the small intestinal action potentials or the speed of gastrointestinal transit of spheres.
在8只狗身上，进行肠切开术、揉搓小肠并使其暴露于空气中，抑制了禁食期间胃肠道中出现的动作电位和收缩的移行性爆发，并极大地减缓了（一至三天）7毫米塑料球在胃肠道中的转运。该手术还导致肾上腺素浓度出现为期一天的短暂升高，以及动脉和静脉血浆中去甲肾上腺素浓度出现为期五天的更长时间升高。甲磺酸酚妥拉明和盐酸普萘洛尔可防止手术引起的胃动作电位爆发的抑制，但这些药物并未改变小肠动作电位的抑制或球体在胃肠道中的转运速度。
