5-羟色胺对大鼠内侧前庭核神经元放电频率的兴奋和抑制作用。

Excitatory and inhibitory effects of 5-hydroxytryptamine on the firing rate of medial vestibular nucleus neurons in the rat.

作者信息

Licata F, Li Volsi G, Maugeri G, Santangelo F

机构信息

Istituto di Fisiologia umana, Università di Catania, Italy.

出版信息

Neurosci Lett. 1993 May 14;154(1-2):195-8. doi: 10.1016/0304-3940(93)90205-y.

DOI:10.1016/0304-3940(93)90205-y

PMID:8361640

Abstract

The effects of microiontophoretic application of 5-hydroxytryptamine (5-HT) on the neuronal firing rate of the medial vestibular nucleus (MVN) were studied in anaesthetized rats. Ninety-three % of the units modified their background activity following 5-HT iontophoresis, enhancements of the firing rate being recorded in 42%, decreases in 38% and biphasic effects in 13%. 5-HT antagonists methysergide and ketanserin blocked the excitatory but not the inhibitory responses to 5-HT. These latter were, however, mimicked by 5-HT agonists 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and 8-hydroxy-2(di-n-propyl-amino)tetralin (8-OH-DPAT). It is concluded that 5-HT can variously influence the background activity of MVN neurons and that 5-HT2 and probably 5-HT1A receptors are involved in the responses.

摘要

在麻醉大鼠中研究了微量离子导入5-羟色胺（5-HT）对内侧前庭核（MVN）神经元放电率的影响。93%的单位在5-HT离子导入后改变了其背景活动，42%记录到放电率增强，38%记录到放电率降低，13%记录到双相效应。5-HT拮抗剂麦角新碱和酮色林阻断了对5-HT的兴奋性反应，但未阻断抑制性反应。然而，5-HT激动剂5-甲氧基-N,N-二甲基色胺（5MeODMT）和8-羟基-2（二正丙基氨基）四氢萘（8-OH-DPAT）模拟了后者的反应。得出的结论是，5-HT可以以多种方式影响MVN神经元的背景活动，并且5-HT2以及可能的5-HT1A受体参与了这些反应。