Sinkiewicz W, Dziedziczko A
Katedry i Kliniki Alergologii i Chorób Wewnetrznych AM, Bydgoszczy.
Pol Tyg Lek. 1993;48(3-4):80-2.
Exercise tolerance was tested with cycloergometer, and ECG recorded in 33 patients with exercise-induced angina pectoris. Patients' age ranged from 36 to 65 years. Tests were performed prior to and after a single oral dose 2 mg of molsidomine or placebo. Molsidomine reduced the number of patients with exercise-induced coronary pain from 33 to 25, i.e. from 84.5% to 27.27%. Pain-free period was significantly longer in patients given molsidomine whereas postexercise pain and total duration of the coronary pain were significantly shorter. Total work was markedly higher, and maximum ST depression in ECG record following exercise was significantly lower than the values noted prior to molsidomine administration and in placebo group. Heart rates both resting and during exercise did not differ in molsidomine and placebo groups. Molsidomine may be considered as an effective drug preventing exercise-induced anginal pain within 1 hour after administration.
使用蹬车测力计测试运动耐量，并对33例运动诱发型心绞痛患者进行心电图记录。患者年龄在36至65岁之间。在单次口服2毫克吗多明或安慰剂之前和之后进行测试。吗多明使运动诱发型冠状动脉疼痛患者数量从33例减少至25例，即从84.5%降至27.27%。服用吗多明的患者无痛期明显更长，而运动后疼痛和冠状动脉疼痛总持续时间明显更短。总功显著更高，运动后心电图记录中的最大ST段压低明显低于服用吗多明之前及安慰剂组所记录的值。吗多明组和安慰剂组的静息心率及运动期间心率无差异。吗多明可被视为一种有效药物，在给药后1小时内可预防运动诱发的心绞痛。
