罗素蝰蛇（Daboia russelii siamensis）咬伤受害者的尿纤维蛋白（原）降解产物

Urinary fibrin (-ogen) degradation products in Russell's viper (Daboia russelii siamensis) bite victims.

作者信息

Han K E, Than T, Lwin M, Swe T N, Pe T

机构信息

Pathology Research Division, Department of Medical Research, Yangon, Myanmar.

出版信息

Southeast Asian J Trop Med Public Health. 1993 Mar;24(1):198-201.

PMID:8362297

Abstract

Serum and urine concentrations of fibrin (-ogen) degradation products (FDP) were estimated in 20 proven Russell's viper bite (RVB) cases with severe defribination. All patients had similar degrees of high serum FDP levels. However, the ten who developed into acute renal failure (ARF) had significantly (p < 0.001) higher urinary FDP levels than those who did not. The urinary FDP levels of ARF cases increased correspondingly with high serum FDP levels but not in cases without ARF. Serial comparison of serum and urinary FDP levels in RVB cases with severe defibrination may be of value in predicting the likelihood of developing ARF. The present study favored disseminated intravascular coagulation as the main cause of ARF in Myanmar RVB cases.

摘要

对20例确诊为严重去纤维蛋白的罗素蝰蛇咬伤（RVB）病例测定了血清和尿液中纤维蛋白（原）降解产物（FDP）的浓度。所有患者血清FDP水平均处于相似的高位。然而，发展为急性肾衰竭（ARF）的10例患者，其尿FDP水平显著（p<0.001）高于未发展为ARF的患者。ARF病例的尿FDP水平随血清FDP高水平相应升高，而非ARF病例则不然。对严重去纤维蛋白的RVB病例的血清和尿FDP水平进行系列比较，可能有助于预测发生ARF的可能性。本研究支持弥散性血管内凝血是缅甸RVB病例中ARF的主要病因。