Leung C S, Hartwick R W, Bédard Y C
Department of Pathology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
Acta Cytol. 1993 Sep-Oct;37(5):645-50.
Different morphologic variants have been described for papillary carcinoma of the thyroid, but little emphasis has been placed on their cytologic patterns. We studied fine needle aspiration (FNA) smears and histologic sections from 48 cases of papillary carcinoma, including 24 of the usual type, 13 of the follicular variant, 7 of the encapsulated variant and 4 of the tall cell variant, in an attempt to correlate the cytologic features and the different histologic variants. Single cells, monolayers and papillary fragments were present in all the variants. The presence of follicles was not restricted to the follicular variant. Nuclear grooves and cytoplasmic pseudoinclusions were present in most of the cases, with nuclear grooves the most common finding in all the variants (92.3-100%). Psammoma bodies were an infrequent finding (0-25%) and were absent from the follicular variant. Colloid was present in all the variants and was a frequent finding in the follicular variant (84.6%). The findings suggest that the exact histologic variant of papillary carcinoma cannot be predicted from the appearance of the fine needle aspirate.
甲状腺乳头状癌已被描述有不同的形态学变异型，但对其细胞学模式的关注较少。我们研究了48例乳头状癌的细针穿刺（FNA）涂片和组织学切片，其中包括24例普通型、13例滤泡状变异型、7例包膜型变异型和4例高细胞变异型，试图将细胞学特征与不同的组织学变异型相关联。所有变异型中均可见单个细胞、单层细胞和乳头状碎片。滤泡的存在并不局限于滤泡状变异型。大多数病例中可见核沟和胞质假包涵体，核沟是所有变异型中最常见的表现（92.3%-100%）。砂粒体较少见（0%-25%），滤泡状变异型中不存在。所有变异型中均有胶质，在滤泡状变异型中较为常见（84.6%）。这些发现表明，无法根据细针穿刺抽吸物的外观预测乳头状癌的确切组织学变异型。
