Karita M, Li Q, Okita K
First Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan.
Am J Gastroenterol. 1993 Sep;88(9):1366-72.
developing a new therapy for eradication of H. pylori by using the nude mouse model.
By quantifying the number of colonies of Helicobacter pylori and the score of H. pylori-associated gastritis from the gastric tissue following different drug regimens in inoculated nude mice, we evaluated the effectiveness of each regimen, including a new drug, plaunotol. Drugs were administered daily for a 1-wk period, beginning 4 wk after inoculation.
In the examination after therapy, the number of colonies of H. pylori and the score of gastritis in the triple-therapy group were significantly lower than in any of the singly- and dual-drug groups or control group from 5 wk to the end of the study after inoculation. Inflammation of the stomach was less apparent in the treatment groups than in the control group.
With the nude mouse model, we quantitatively demonstrated that the new triple therapy is the most effective therapy for eradication of H. pylori.
利用裸鼠模型开发一种根除幽门螺杆菌的新疗法。
通过对接种裸鼠采用不同药物治疗方案后，对胃组织中幽门螺杆菌菌落数和幽门螺杆菌相关性胃炎评分进行量化，我们评估了每种方案的有效性，包括一种新药，普伐他汀。接种后4周开始，每天给药，持续1周。
治疗后的检查中，从接种后5周直至研究结束，三联疗法组中幽门螺杆菌菌落数和胃炎评分显著低于单药组、双药组或对照组中的任何一组。治疗组的胃部炎症比对照组不明显。
通过裸鼠模型，我们定量证明了新的三联疗法是根除幽门螺杆菌最有效的疗法。
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