Bergin P S, Miller D H, Hirsch N P, Murray N M
National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Ann Neurol. 1993 Sep;34(3):406-9. doi: 10.1002/ana.410340318.
3,4-Diaminopyridine was administered to 6 patients with inflammatory demyelinating neuropathies in whom partial conduction block was demonstrable. Four had Guillain-Barré syndrome and 2 had chronic inflammatory demyelinating neuropathy. Nerve conduction studies were performed before the administration of a single oral dose of 3,4-diaminopyridine, and at regular intervals thereafter. Neither resolution of conduction block nor clinical benefit were seen.
对6例炎症性脱髓鞘性神经病且可证实存在部分传导阻滞的患者给予3,4 - 二氨基吡啶治疗。其中4例患有格林 - 巴利综合征，2例患有慢性炎症性脱髓鞘性神经病。在单次口服3,4 - 二氨基吡啶之前及之后定期进行神经传导研究。未观察到传导阻滞的缓解及临床获益。
