Collins R, Beattie S, Xia H X, O'Morain C
Department of Gastroenterology, Meath/Adelaide Hospitals, Dublin, Eire.
Aliment Pharmacol Ther. 1993 Jun;7(3):313-5. doi: 10.1111/j.1365-2036.1993.tb00102.x.
Thirteen consecutive patients with active duodenal ulcer disease were assigned to a treatment schedule with high-dose omeprazole and amoxycillin. Duodenal ulcer was diagnosed endoscopically in all patients, at which time antral biopsies were taken for culture and histology. All were positive for Helicobacter pylori and histological gastritis. Treatment was for 2 weeks: 80 mg omeprazole daily plus 500 mg amoxycillin syrup t.d.s. in the first week, followed by 40 mg omeprazole daily in the second week. Repeat gastroscopy was performed 4 weeks after completion of treatment in all patients. Duodenal ulcer healing occurred in 4/13 patients. H. pylori eradication was achieved in 2/4 patients with healed ulcers and in 3/9 patients with persistent ulceration. This study suggests that a short period of treatment with high-dose omeprazole and amoxycillin achieves low rates of ulcer healing and H. pylori eradication.
连续13例活动性十二指肠溃疡患者被安排接受大剂量奥美拉唑和阿莫西林的治疗方案。所有患者均经内镜诊断为十二指肠溃疡，此时取胃窦活检进行培养和组织学检查。所有患者幽门螺杆菌及组织学胃炎均呈阳性。治疗为期2周：第一周每日80mg奥美拉唑加500mg阿莫西林糖浆，每日3次，第二周每日40mg奥美拉唑。所有患者在治疗结束4周后进行重复胃镜检查。13例患者中有4例十二指肠溃疡愈合。4例溃疡愈合患者中有2例幽门螺杆菌根除，9例持续性溃疡患者中有3例幽门螺杆菌根除。本研究表明，短期使用大剂量奥美拉唑和阿莫西林治疗，溃疡愈合率和幽门螺杆菌根除率较低。
