Hirayama Y, Kohgo Y, Kanisawa Y, Fujii S, Ikeda K, Matsunaga T, Ito Y, Sakamaki S, Niitsu Y
Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
Int J Hematol. 1993 Jun;57(3):265-8.
We report a 19-year-old female with blastic transformation of chronic myelogenous leukemia whose blasts had CD33 and CD4 phenotypes, although no significant characteristics were detected by morphological and histochemical analysis. In a colony assay with hematopoietic growth factors, the blasts proliferated and differentiated into myelo-monocytic lineage, particularly in the presence of GM-CSF or IL-3 + G-CSF. The blasts transformed from CML were assumed to be myelo-monocytic progenitor cells, corresponding to GM colonies. Blastic transformation expressing such a phenotype has not been reported previously.
