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Nucleosides and nucleotides. CXIX. Inhibition of DNA-cytosine methylase HhaI by a self-complementary oligonucleotide containing 5-fluorocytosine.

作者信息

Ono A, Matsuo Y, Matsuda A, Ueda T

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

Biol Pharm Bull. 1993 Jun;16(6):529-33. doi: 10.1248/bpb.16.529.

DOI:10.1248/bpb.16.529
PMID:8364503
Abstract

A self-complementary decadeoxyribonucleotide, 5'd(GAAGFGCTTC)3', containing 5-fluorocytosine (F) in substitution for cytosine at the methylation site of DNA-cytosine methylase HhaI (MHhaI) has been synthesized. MHhaI was inhibited by the pre-incubation of the enzyme with d(GAAGFGCTTC).

摘要

相似文献

1
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2
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