Madorsky M L, Finlayson B
Invest Urol. 1977 Jan;14(4):274-7.
An animal experimental model was used to study oxalate absorption from the gut. It was found that the initial rate of [14C]oxalate absorption is rapid (6.5 per cent per min), and that after 5 min the rate of absorption decreases to about 0.6 per cent per min. Absorption of [14C]oxalate was greatest in the jejunum and least in the colon. On the basis of linear coefficients derived from the data, it is estimated that at least 8.6 per cent of a challenge dose of oxalate should be absorbed from the small bowel during normal transit. The high absorption rate, compared with the normal absorption of oxalate, in this model is most likely attributable to the oxalate's being completely dissolved in the gut. Magnesium and calcium in the test solution did not cause large changes in the rate or amount of oxalate transfer in this experimental model.
使用动物实验模型来研究草酸盐从肠道的吸收情况。研究发现，[14C]草酸盐的初始吸收速率很快（每分钟6.5%），5分钟后吸收速率降至约每分钟0.6%。[14C]草酸盐在空肠的吸收最多，在结肠的吸收最少。根据从数据得出的线性系数估计，在正常转运过程中，至少8.6%的草酸盐激发剂量应从小肠吸收。与草酸盐的正常吸收相比，该模型中较高的吸收速率很可能归因于草酸盐在肠道中完全溶解。测试溶液中的镁和钙在该实验模型中并未引起草酸盐转运速率或转运量的大幅变化。
