Sessa A, Broglia E, Terreni M R, Perin A
Consiglio Nazionale delle Ricerche, Centro di Studio sulla Patologia Cellulare, Milano, Italy.
Cancer Lett. 1993 Jul 30;71(1-3):183-7. doi: 10.1016/0304-3835(93)90114-o.
In the early stages of brain carcinogenesis induced by transplacental administration of N-ethyl-N-nitrosourea to BD IX rats, a constant increase in the activity of cerebral diamine oxidase, the rate-limiting enzyme in terminal catabolism of polyamines, was observed. Gliomas, which developed between the fifth and eight month of extrauterine life, showed an 8-fold increase in enzyme activity compared with normal brain from rats of the same age. Concomitantly, an 11-fold enhancement in putrescine, a physiological substrate of diamine oxidase, was also found. Such findings indicate that an increase in oxidative putrescine catabolism via diamine oxidase takes place in transformed cells and in gliomas and is probably linked to an activation of polyamine synthesis and turnover.
通过向BD IX大鼠经胎盘给予N-乙基-N-亚硝基脲诱导脑癌发生的早期阶段，观察到多胺终末分解代谢中的限速酶——脑二胺氧化酶的活性持续增加。在出生后5至8个月之间发生的胶质瘤，与同年龄大鼠的正常脑相比，酶活性增加了8倍。同时，还发现二胺氧化酶的生理底物腐胺增加了11倍。这些发现表明，在转化细胞和胶质瘤中，通过二胺氧化酶的氧化腐胺分解代谢增加，并且可能与多胺合成和周转的激活有关。
