Tanaka K, Nakamura M, Domen M, Arimitsu M, Izumi T, Okuda T, Suekane K, Tezuka T
Department of Anesthesiology, Kinki University School of Medicine, Osaka-Sayama, Japan.
Clin Ther. 1993 May-Jun;15(3):567-9.
To examine the relationship between volatile inhalation anesthetics and the fading of portwine stain (PWS), the study retrospectively investigated the incidence of termination of pulsed dye laser treatment vis-à-vis PWS fade during use of a general inhalation anesthetic in 107 infants and children with facial PWS. The fading of PWS is disadvantageous to the pulsed dye laser treatment. All patients received pulsed dye laser treatment under general anesthesia using one of four kinds of volatile inhalation anesthetics (halothane, enflurane, isoflurane, and sevoflurane). Two hours before the induction of anesthesia, all patients were rectally irrigated. Treatment was discontinued in none of the 44 patients in the halothane group or the 7 patients in the enflurane group; in one of the 29 in the isoflurane group; and in 10 of the 27 patients in the sevoflurane group. The sevoflurane group showed a significantly (P < 0.01) higher incidence of PWS fading. Thus, when using a volatile inhalation anesthetic in combination with pulsed dye laser treatment for PWS, caution should be exercised if sevoflurane is selected, as PWS fading is harmful to the pulsed dye laser.
为研究挥发性吸入麻醉剂与葡萄酒色斑（PWS）消退之间的关系，该研究回顾性调查了107例面部患有PWS的婴幼儿在使用全身吸入麻醉剂期间，脉冲染料激光治疗终止率与PWS消退情况的相关性。PWS的消退不利于脉冲染料激光治疗。所有患者均在全身麻醉下使用四种挥发性吸入麻醉剂（氟烷、安氟醚、异氟醚和七氟醚）之一接受脉冲染料激光治疗。麻醉诱导前两小时，所有患者均进行直肠灌洗。氟烷组44例患者和安氟醚组7例患者均未中断治疗；异氟醚组29例中有1例中断治疗；七氟醚组27例中有10例中断治疗。七氟醚组PWS消退发生率显著更高（P<0.01）。因此，在将挥发性吸入麻醉剂与脉冲染料激光联合用于治疗PWS时，若选择七氟醚应谨慎，因为PWS消退对脉冲染料激光治疗有害。
