Giudice G J, Diaz L A
Department of Dermatology, Medical College of Wisconsin, Milwaukee.
Dermatol Clin. 1993 Jul;11(3):419-27.
Over the last 5 to 10 years, basic research in the areas of cell biology, biochemistry, immunology, and molecular biology has led to quantum advances in our understanding of the causes of the bullous diseases. This explosion of new information has been made possible by corresponding technologic advances related to these scientific disciplines. This article does not represent a comprehensive review of this topic, but rather highlights important contributions primarily from the field of molecular biology. Much of this article describes research technologies aimed at identifying and characterizing the genes and gene products that are directly involved in the pathogenesis of the bullous disorders. Although many significant advances have been made, a great deal remains to be done. It is our hope that the next 5 to 10 years will witness the emergence of a new set of technologies that will facilitate the translation of this new-found molecular information into more accurate diagnostic tools, more effective therapeutic strategies, and a fuller understanding of the basic biology of the skin.
在过去5到10年里，细胞生物学、生物化学、免疫学和分子生物学领域的基础研究使我们对大疱性疾病病因的理解取得了重大进展。这些新信息的激增得益于与这些科学学科相关的相应技术进步。本文并非对该主题的全面综述，而是主要突出分子生物学领域的重要贡献。本文大部分内容描述了旨在识别和表征直接参与大疱性疾病发病机制的基因和基因产物的研究技术。尽管已经取得了许多重大进展，但仍有大量工作要做。我们希望在未来5到10年里，会出现一套新的技术，将这些新发现的分子信息转化为更准确的诊断工具、更有效的治疗策略，并更全面地理解皮肤的基础生物学。
