Bischof P
Department of Obstetrics and Gynecology, University of Geneva, Switzerland.
Eur J Obstet Gynecol Reprod Biol. 1993 Apr;49(1-2):93-8. doi: 10.1016/0028-2243(93)90131-u.
The murine monoclonal antibody OC 125 recognizes an epitope on a molecule called Cancer Antigen 125 (CA 125). The CA 125 antigen is expressed in amnion and its derivatives of fetal coelomic epithelia (such as Müllerian epithelia, peritoneum, pleura and pericardium) and in many adult tissues (such as the epithelium of fallopian tubes, endometrium, endocervix, pleura and peritoneum). The normal endometrium produces CA 125 and this production can contribute significantly to the level of circulating CA 125 at the time of menstruation. During peritoneal irritation (hyperstimulation, salpingitis, ruptured ectopic pregnancy, laparotomy) peritoneally derived CA 125 significantly contributes to circulating CA 125 concentrations, giving elevated CA 125 values. The use of the CA 125 serum assay as a single diagnostic tool is restricted by the fact that the antigen CA 125 is produced by normal epithelia (of peritoneum, endometrium and benign ovarian cysts) and not only by the ovarian cancer cell.
鼠单克隆抗体OC 125识别一种名为癌抗原125（CA 125）的分子上的一个表位。CA 125抗原在羊膜及其胎儿体腔上皮衍生物（如苗勒氏上皮、腹膜、胸膜和心包）以及许多成年组织（如输卵管上皮、子宫内膜、子宫颈内膜、胸膜和腹膜）中表达。正常子宫内膜会产生CA 125，这种产生在月经期间可显著影响循环CA 125的水平。在腹膜刺激（过度刺激、输卵管炎、异位妊娠破裂、剖腹手术）期间，腹膜来源的CA 125对循环CA 125浓度有显著影响，导致CA 125值升高。由于抗原CA 125不仅由卵巢癌细胞产生，也由正常上皮（腹膜、子宫内膜和良性卵巢囊肿的上皮）产生，因此将CA 125血清检测作为单一诊断工具受到限制。
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