正常血压和去窦主动脉神经大鼠下丘脑前部的去甲肾上腺素能-γ-氨基丁酸能相互作用

Noradrenergic-GABAergic interaction in anterior hypothalamus from normotensive and sinoaortic denervated rats.

Solignac D, Enero M A

Instituto de Investigaciones Farmacológicas--CONICET, Buenos Aires, Argentina.

Gen Pharmacol. 1993 May;24(3):763-8. doi: 10.1016/0306-3623(93)90243-q.

Abstract

GABA content is decreased in anterior hypothalamus and medulla oblongata of hypertensive rats by sinoaortic denervation (SAD) when compared to control animals which underwent a sham-operation (sham). 2. Lesion of noradrenergic pathways by 6-hydroxydopamine (6-OHDA), intracerebroventricularly administered, induced depletion of noradrenergic content in frontal cortex, anterior and posterior hypothalamus in both SAD and sham-operated rats. 3. As a consequence of this noradrenergic depletion there was an increase of GABA content in anterior hypothalamus only, from sham- and SAD-operated animals, without changes in other areas. 4. There is a noradrenergic-GABAergic interaction in the anterior hypothalamus of normotensive rats which is not impaired in hypertensive rats by sinoaortic denervation.

摘要

与接受假手术（假手术组）的对照动物相比，经窦主动脉去神经支配（SAD）的高血压大鼠下丘脑前部和延髓中的γ-氨基丁酸（GABA）含量降低。2. 脑室内注射6-羟基多巴胺（6-OHDA）损伤去甲肾上腺素能通路，导致SAD组和假手术组大鼠额叶皮质、下丘脑前部和后部的去甲肾上腺素能含量耗竭。3. 由于这种去甲肾上腺素能耗竭，仅在假手术组和SAD组动物的下丘脑前部，GABA含量增加，其他区域无变化。4. 正常血压大鼠下丘脑前部存在去甲肾上腺素能-γ-氨基丁酸能相互作用，经窦主动脉去神经支配的高血压大鼠中这种相互作用未受损。