Wolf P, Ochsendorf F R, Milbradt R
Abteilung II, Klinikum der J.W. Goethe Universität Frankfurt/Main.
Hautarzt. 1993 Jul;44(7):462-5.
The recommendations for the treatment of cutaneous larva migrans are not uniform, and the recommended methods are neither always available nor always effective. If only the skin is affected, primarily topical therapy is indicated. Topical thiabendazole combines efficacy with missing systemic side-effects. In Germany the pure substance has to be used or Mintezol tablets must be purchased from abroad. Topical mebendazole and freezing with liquid nitrogen are less effective and involve side-effects. If topical treatment fails, systemic therapy is required. The recognized treatment with oral thiabendazole (2 days) is associated with numerous side-effects. There are now two new, safer drugs that should be preferred: albendazole (400 mg/day for 3 days), available in Germany as Eskazole, or ivermectin (single dose of 200 micrograms/kg). The latter can be ordered from the manufacturer under the trade name of Mectizan.
皮肤幼虫移行症的治疗建议并不统一,推荐的治疗方法既非总能获得,也并非总是有效。如果仅皮肤受累,主要采用局部治疗。局部使用噻苯达唑疗效良好且无全身副作用。在德国必须使用纯品,或者必须从国外购买敏特唑片。局部使用甲苯达唑和液氮冷冻效果较差且有副作用。如果局部治疗失败,则需要全身治疗。公认的口服噻苯达唑(2天)治疗有许多副作用。现在有两种更安全的新药应优先选用:阿苯达唑(400毫克/天,共3天),在德国以Eskazole出售,或伊维菌素(单剂量200微克/千克)。后者可从制造商处订购,商品名为美迪善。