吡嗪甲酰胍与氢氯噻嗪对肾功能不全患者的不同作用

Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.

作者信息

Beyer K H, Ward T D, Vary J E, Gelarden R T, Knutson D W, Vesell E S

机构信息

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.

出版信息

J Clin Pharmacol. 1993 Jun;33(6):554-61. doi: 10.1002/j.1552-4604.1993.tb04703.x.

DOI:10.1002/j.1552-4604.1993.tb04703.x

PMID:8366180

Abstract

A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.

摘要

一项带有洗脱期的单盲交叉研究表明，吡嗪甲酰胍（PZG）可降低肾功能不全患者升高的血清尿素、甘油三酯和胆固醇浓度。吡嗪甲酰胍具有促尿钠排泄作用，且不影响血清钾或葡萄糖浓度。PZG的降压作用在4小时内起效。相比之下，氢氯噻嗪（HCTZ）会升高血清尿素、甘油三酯和葡萄糖浓度，但不影响胆固醇。