Prather R D, Tu T G, Rolf C N, Gorsline J
ALZA Corporation, Palo Alto, CA 94303-0802.
J Clin Pharmacol. 1993 Jul;33(7):644-9. doi: 10.1002/j.1552-4604.1993.tb04718.x.
This study examined the effect of gender and body weight on the pharmacokinetic properties of the Nicotine Transdermal System (NTS) (Nicoderm). This NTS was applied for 24 hours to 13 normal-sized men, 13 women, and 13 obese men, all of whom were smokers who had abstained from cigarettes for the previous 24 hours. Pharmacokinetic parameters were determined during a single application of the system. The mean nicotine maximal plasma concentration (Cmax) and area under the curve (AUC) values for women did not differ significantly from those for normal-sized men. Nicotine Cmax and AUC values, however, were significantly lower in obese compared with normal-sized men; nicotine AUC was strongly correlated to body weight and body mass index. Mean apparent nicotine elimination rate constant values were not significantly different between normal-sized and obese men, but the apparent elimination rate constant value was significantly higher in women. The possible clinical significance of the differences in nicotine AUC values with body weight is discussed.
本研究考察了性别和体重对尼古丁透皮系统（NTS，商品名Nicoderm）药代动力学特性的影响。该NTS在13名正常体型男性、13名女性和13名肥胖男性身上应用24小时，所有受试者均为吸烟者，且在之前24小时内已戒烟。在系统单次应用期间测定药代动力学参数。女性的尼古丁平均最大血浆浓度（Cmax）和曲线下面积（AUC）值与正常体型男性相比无显著差异。然而，肥胖男性的尼古丁Cmax和AUC值显著低于正常体型男性；尼古丁AUC与体重和体重指数密切相关。正常体型男性和肥胖男性的平均表观尼古丁消除速率常数无显著差异，但女性的表观消除速率常数显著更高。文中讨论了尼古丁AUC值随体重变化的差异可能具有的临床意义。
