Purves D, LaMantia A
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
J Comp Neurol. 1993 Aug 8;334(2):169-75. doi: 10.1002/cne.903340202.
We have examined the area of the primary visual cortex and the number and size of blobs within it in 10 neonatal and 11 adult rhesus monkeys. The average area of the primary visual cortex (V1) increases from 919 mm2 in newborns to 1,069 mm2 in adult animals (16%). The number of blobs decreases per unit area from an average of 5.2/mm2 at birth to 4.3/mm2 in maturity (18%). As a consequence, the number of blobs remains approximately the same during maturation, at about 4,800/hemisphere. These observations correct a preliminary report on a subset of the animals studied here (Purves and LaMantia: Proc Natl Acad Sci 87:5765, '90), in which it appeared that blob number might increase between birth and maturity. As in other regions of the developing postnatal brain, we found no net loss of modular circuitry.
我们检查了10只新生恒河猴和11只成年恒河猴的初级视觉皮层面积及其内部斑点的数量和大小。初级视觉皮层（V1）的平均面积从新生儿的919平方毫米增加到成年动物的1069平方毫米（增加了16%）。每单位面积的斑点数量从出生时的平均每平方毫米5.2个减少到成熟时的每平方毫米4.3个（减少了18%）。因此，在成熟过程中斑点数量大致保持不变，每半球约为4800个。这些观察结果纠正了在此研究的部分动物的初步报告（Purves和LaMantia：《美国国家科学院院刊》87:5765，'90），该报告显示斑点数量在出生到成熟之间可能会增加。与出生后发育中的大脑其他区域一样，我们没有发现模块化电路的净损失。
