Oikawa M, Katayama Y, Yoshihara T, Kaneko M, Yoshikawa T
Pathology Division, Japan Racing Association, Tokyo.
J Comp Pathol. 1993 May;108(4):411-5. doi: 10.1016/s0021-9975(08)80214-9.
The morphology of the arteries in the uterine wall was studied in three multiparous aged mares that had suffered repeated pregnancy failure. The uterine wall arteries exhibited elastosis of the intima or adventitia, or both, resembling "physiological pregnancy sclerosis". In areas affected by elastosis, degeneration of the pre-existing elastic fibres and increased glycosaminoglycans were frequently observed. Newly formed elastic fibres were not evident. Delayed resorption due to disordered metabolic turnover of the elastin was thought to be an important factor in the pathogenesis of the arterial elastosis in the uterine wall.
对三头经产老龄母马的子宫壁动脉形态进行了研究，这些母马反复出现妊娠失败。子宫壁动脉表现出内膜或外膜或两者的弹性组织变性，类似于“生理性妊娠硬化”。在受弹性组织变性影响的区域，经常观察到原有弹性纤维的退化和糖胺聚糖的增加。未见新形成的弹性纤维。由于弹性蛋白代谢周转紊乱导致的吸收延迟被认为是子宫壁动脉弹性组织变性发病机制中的一个重要因素。
