Chevrant-Breton J, Simon M, Bourel M, Ferrand B
Arch Dermatol. 1977 Feb;113(2):161-5.
Skin manifestations of idiopathic hemochromatosis (IH) are presented in 100 cases with emphasis on the previously unrecognized high frequency of ichthyosis-like states and koilonychia. In 50 cases with treated and nontreated groups, histological siderosis and clinical skin pigmentation were found to decrease postphlebotomy whereas melanosis, histologically, did not. By skin biopsy in 50 cases versus controls, the location of siderosis in eccrine sweat glands seems specific for IH providing a strong basis for a probable diagnosis of the disease. There are correlations between skin manifestations and other signs of the disease.
本文报告了100例特发性血色素沉着症（IH）的皮肤表现，重点关注此前未被认识到的类似鱼鳞病状态和匙状甲的高发病率。在50例分为治疗组和未治疗组的病例中，发现组织学上的铁质沉着和临床皮肤色素沉着在放血治疗后有所减轻，而黑色素沉着在组织学上并未减轻。通过对50例病例与对照组进行皮肤活检，发现小汗腺中铁质沉着的位置似乎是特发性血色素沉着症所特有的，这为该病的可能诊断提供了有力依据。皮肤表现与该疾病的其他体征之间存在相关性。
