阿尔茨海默病中神经毡丝的形态计量图像分析。

Morphometric image analysis of neuropil threads in Alzheimer's disease.

作者信息

Markesbery W R, Wang H Z, Kowall N W, Kosik K S, McKee A C

机构信息

Department of Pathology (Neuropathology) and Neurology, University of Kentucky Medical Center, Lexington 40536.

出版信息

Neurobiol Aging. 1993 Jul-Aug;14(4):303-7. doi: 10.1016/0197-4580(93)90115-r.

DOI:10.1016/0197-4580(93)90115-r

PMID:8367011

Abstract

Neuropil threads were quantitated in the neuropil (excluding senile plaques) of the superior frontal gyrus of 6 late stage patients with Alzheimer's disease (AD) and 6 age-matched control subjects using tau immunocytochemistry and computerized morphometric image analysis. The mean percent of the area of the neuropil occupied by neuropil threads was 10.6 for AD and 0.19 for controls (p < 1 x 10(-10)). The mean length of neuropil threads in AD was 21.9 mu compared with 19.7 mu for controls (p < 1 x 10(-10)). The mean area of neuropil threads was 25.3 mu 2 for AD and 21.3 mu 2 for controls (p < 1 x 10(-10)). In AD, the threads were most prominent in mid cortex (lamina 2 and 3) and least prominent in the lower cortex (lamina 5 and 6). Neuropil threads appear to lead to severe disorganization of intracortical and corticocortical connectivity and probably play a role in the cognitive failure in AD.

摘要

使用tau免疫细胞化学和计算机形态计量图像分析，对6例晚期阿尔茨海默病（AD）患者和6例年龄匹配的对照受试者额叶上回的神经毡（不包括老年斑）中的神经原纤维丝进行定量分析。AD患者神经原纤维丝占据神经毡面积的平均百分比为10.6%，而对照组为0.19%（p < 1×10⁻¹⁰）。AD患者神经原纤维丝的平均长度为21.9微米，而对照组为19.7微米（p < 1×10⁻¹⁰）。AD患者神经原纤维丝的平均面积为25.3平方微米，而对照组为21.3平方微米（p < 1×10⁻¹⁰）。在AD中，神经原纤维丝在皮质中部（第2和第3层）最为突出，而在皮质下部（第5和第6层）最不突出。神经原纤维丝似乎导致皮质内和皮质间连接的严重紊乱，并且可能在AD的认知功能障碍中起作用。