Guan S, Wahl M C, Wood T D, Marshall A G
Department of Chemistry, Ohio State University, Columbus 43210.
Anal Chem. 1993 Jul 1;65(13):1753-7. doi: 10.1021/ac00061a019.
Ion cooling and axialization produced by azimuthal quadrupolar excitation in the presence of ion-neutral collisions are applied to laser desorption Fourier transform ion cyclotron resonance mass spectrometry (LD/FT/ICR-MS). With this technique, the large kinetic and internal energies of ions generated by laser desorption processes can be cooled effectively by collisions of ions with neutral argon atoms (at > 5 x 10(-7) Torr). After sufficient cooling in the source compartment of a dual ion trap, the axialized ions may be transferred to the analyzer compartment for detection at much lower pressure (and thus much higher mass resolving power). Enhancements in both FT/ICR mass resolving power and sensitivity are observed; moreover, ion isolation with high selectivity at high pressure is also demonstrated.
在存在离子 - 中性碰撞的情况下，由方位四极激发产生的离子冷却和轴向化被应用于激光解吸傅里叶变换离子回旋共振质谱（LD/FT/ICR-MS）。通过这种技术，激光解吸过程产生的离子的大动能和内能可以通过离子与中性氩原子的碰撞（在大于5×10⁻⁷托的压力下）有效地冷却。在双离子阱的源区充分冷却后，轴向化的离子可以转移到分析区，在低得多的压力下（从而具有高得多的质量分辨能力）进行检测。观察到FT/ICR质量分辨能力和灵敏度都有所提高；此外，还证明了在高压下具有高选择性的离子隔离。
