Salles G, Vignal M, Ninet J, Berger F, Coiffier B, Girard-Madoux M H, Coppéré B, Ravault M, Pasquier J
Service d'Hématologie, Hôpital Edouard-Herriot, Lyon.
Ann Med Interne (Paris). 1993;144(3):168-72.
Over an 8-year period in the Departments of Hematology, Ophthalmology and Internal Medicine of our hospital, 12 cases of orbital and adnexal malignant non-Hodgkin's lymphoma were reported. Diagnostic elements varied, including local tumefaction, watering eyes, uveitis, and unexplained, long-term fever. Nine patients had primary paraocular lymphomas involving either orbital structures, the lacrimal gland or the eyeball, but after appropriate staging, the disease was found to be disseminated in 5; the 3 other cases were secondary orbital lymphomas. Intermediate or high grade histological types were predominant (9 patients) in our series. Radiation therapy, alone or combined (5 patients) with chemotherapy, was administered in 8 cases; other treatments consisted of chemotherapy (2 cases) or steroids (2 cases). Evolution was poor, with only 4 patients surviving at 34-180 months of follow-up. The main prognostic factors were tumor stage and histological grade. The clinical characteristics of this group are compared to those reported in the literature.
在我院血液科、眼科和内科的8年时间里，共报告了12例眼眶及附属器恶性非霍奇金淋巴瘤。诊断依据各不相同，包括局部肿胀、流泪、葡萄膜炎以及不明原因的长期发热。9例患者患有原发性眼周淋巴瘤，累及眼眶结构、泪腺或眼球，但经适当分期后，发现5例患者的疾病已扩散；另外3例为继发性眼眶淋巴瘤。在我们的系列研究中，中高级组织学类型占主导（9例患者）。8例患者接受了单独放疗或放疗联合（5例患者）化疗；其他治疗包括化疗（2例）或类固醇治疗（2例）。病情进展不佳，随访34 - 180个月时仅有4例患者存活。主要预后因素为肿瘤分期和组织学分级。将该组患者的临床特征与文献报道的特征进行了比较。
