Influence of amytal and menadione on high-energy phosphates and acid secretion in frog gastric mucosa.
作者信息
Hersey S J
出版信息
Biochim Biophys Acta. 1977 Feb 28;496(2):359-66. doi: 10.1016/0304-4165(77)90318-x.
PMID:836902
Abstract
Measurement of ATP and creatine phosphate in isolated frog gastric mucosa showed that amytal depressed the level of both high-energy compounds and inhibited acid secretion. Addition of menadione restored the ATP level to control values and partially restored the creatine phosphate levels but did not support acid secretion. Menadione was found to support that portion of active chloride transport which is not associated with acid output. It is concluded that an amytal-sensitive reaction, presumably mitochondrial coupling site I, is required for acid secretion to occur and that ATP is not a sufficient source of energy for this secretory process.
摘要
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引用本文的文献
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