单事件记录表明，与受体结合会改变由流感血凝素介导的膜融合动力学。
Single event recording shows that docking onto receptor alters the kinetics of membrane fusion mediated by influenza hemagglutinin.
作者信息
Niles W D, Cohen F S
机构信息
Department of Physiology, Rush Medical College, Chicago, Illinois 60612.
出版信息
Biophys J. 1993 Jul;65(1):171-6. doi: 10.1016/S0006-3495(93)81049-X.
Abstract
The initial steps of membrane fusion, receptor binding and membrane destabilization, are mediated by the envelope glycoprotein hemagglutinin of influenza virus. Interaction between these functions was determined from the time course of individual virion fusions to a planar membrane with and without receptor. With receptor, fusion was described by a Poisson process. In the absence of receptor, the time course was more complicated and could not be described with exponential rate constants. The conversion of a non-Markovian process into a simple Markov chain is direct evidence that receptor binding fundamentally alters the route of fusion.
摘要
膜融合、受体结合和膜去稳定化的初始步骤由流感病毒的包膜糖蛋白血凝素介导。这些功能之间的相互作用是根据单个病毒粒子与有或无受体的平面膜融合的时间进程来确定的。有受体时，融合由泊松过程描述。在没有受体的情况下，时间进程更为复杂，无法用指数速率常数来描述。将非马尔可夫过程转化为简单的马尔可夫链直接证明受体结合从根本上改变了融合途径。
相似文献
1
Single event recording shows that docking onto receptor alters the kinetics of membrane fusion mediated by influenza hemagglutinin.
Biophys J. 1993 Jul;65(1):171-6. doi: 10.1016/S0006-3495(93)81049-X.
2
Membrane fusion. Anchors aweigh.
Curr Biol. 1994 Jun 1;4(6):551-4. doi: 10.1016/s0960-9822(00)00123-8.
3
Kinetics of the low pH-induced conformational changes and fusogenic activity of influenza hemagglutinin.
Biophys J. 1994 Dec;67(6):2355-60. doi: 10.1016/S0006-3495(94)80721-0.
4
Analyzing the fusion process of influenza hemagglutinin by mutagenesis and molecular modeling.
Biophys J. 1992 Apr;62(1):95-7. doi: 10.1016/S0006-3495(92)81790-3.
5
Temperature-dependent kinetics of the activities of influenza virus.
J Struct Biol. 1990 Jul-Sep;104(1-3):63-9. doi: 10.1016/1047-8477(90)90058-k.
6
Fusion flashes illuminate kinetics.
Biophys J. 1993 Jul;65(1):7-8. doi: 10.1016/S0006-3495(93)81023-3.
7
A mechanism of protein-mediated fusion: coupling between refolding of the influenza hemagglutinin and lipid rearrangements.
Biophys J. 1998 Sep;75(3):1384-96. doi: 10.1016/S0006-3495(98)74056-1.
8
A dissection of steps leading to viral envelope protein-mediated membrane fusion.
Ann N Y Acad Sci. 1991;635:285-96. doi: 10.1111/j.1749-6632.1991.tb36499.x.
9
Effect of X31 influenza virus fusion on phosphatidylserine asymmetry in erythrocytes.
Biochim Biophys Acta. 1996 Jan 12;1278(1):98-104. doi: 10.1016/0005-2736(95)00193-x.
10
Fusion characteristics of influenza C viruses.
J Gen Virol. 1990 May;71 ( Pt 5):1181-8. doi: 10.1099/0022-1317-71-5-1181.
引用本文的文献
1
Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2.
Int J Mol Sci. 2022 Jul 1;23(13):7365. doi: 10.3390/ijms23137365.
2
Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor.
Pathogens. 2020 May 27;9(6):416. doi: 10.3390/pathogens9060416.
3
Stochastic fusion simulations and experiments suggest passive and active roles of hemagglutinin during membrane fusion.
Biophys J. 2014 Feb 18;106(4):843-54. doi: 10.1016/j.bpj.2013.12.048.
4
Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.
Anal Chem. 2012 Oct 16;84(20):8480-9. doi: 10.1021/ac3006473. Epub 2012 Oct 1.
5
Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion.
Viruses. 2012 Jul;4(7):1144-68. doi: 10.3390/v4071144. Epub 2012 Jul 24.
6
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
Crit Rev Biochem Mol Biol. 2008 May-Jun;43(3):189-219. doi: 10.1080/10409230802058320.
7
Comprehensive kinetic analysis of influenza hemagglutinin-mediated membrane fusion: role of sialate binding.
Biophys J. 2001 Sep;81(3):1521-35. doi: 10.1016/S0006-3495(01)75806-7.
8
Delay of influenza hemagglutinin refolding into a fusion-competent conformation by receptor binding: a hypothesis.
Biophys J. 2000 Sep;79(3):1415-27. doi: 10.1016/S0006-3495(00)76393-4.
9
Fusion flashes illuminate kinetics.
Biophys J. 1993 Jul;65(1):7-8. doi: 10.1016/S0006-3495(93)81023-3.
本文引用的文献
1
The nature of the virus receptors of red cells; evidence on the chemical nature of the virus receptors of red cells and of the existence of a closely analogous substance in normal serum.
J Exp Med. 1948 Apr 1;87(4):301-14. doi: 10.1084/jem.87.4.301.
2
THE MEASUREMENT OF SYNAPTIC DELAY, AND THE TIME COURSE OF ACETYLCHOLINE RELEASE AT THE NEUROMUSCULAR JUNCTION.
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:483-95. doi: 10.1098/rspb.1965.0016.
3
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
Nature. 1981 Jan 29;289(5796):366-73. doi: 10.1038/289366a0.
4
Influenza viruses cause hemolysis and fusion of cells.
Virology. 1981 Apr 15;110(1):243-7. doi: 10.1016/0042-6822(81)90030-1.
5
Membrane fusion activity of influenza virus.
EMBO J. 1982;1(2):217-22. doi: 10.1002/j.1460-2075.1982.tb01150.x.
6
Infectious cell entry mechanism of influenza virus.
J Virol. 1982 Jul;43(1):284-93. doi: 10.1128/JVI.43.1.284-293.1982.
7
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.
Proc Natl Acad Sci U S A. 1982 Feb;79(4):968-72. doi: 10.1073/pnas.79.4.968.
8
Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin.
Virology. 1983 Jun;127(2):361-73. doi: 10.1016/0042-6822(83)90150-2.
9
Membrane fusion proteins of enveloped animal viruses.
Q Rev Biophys. 1983 May;16(2):151-95. doi: 10.1017/s0033583500005072.
10
Monoclonal anti-hemagglutinin antibodies detect irreversible antigenic alterations that coincide with the acid activation of influenza virus A/PR/834-mediated hemolysis.
J Virol. 1983 Oct;48(1):239-48. doi: 10.1128/JVI.48.1.239-248.1983.
Zotero 插件