Linden D J, Connor J A
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Curr Opin Neurobiol. 1993 Jun;3(3):401-6. doi: 10.1016/0959-4388(93)90133-j.
Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided strong evidence that two mechanisms, Ca2+ influx via voltage-gated channels, and stimulation of protein kinase C via metabotropic receptor activation, are required for induction of long-term depression. In addition, two other mechanisms, Na+ influx via AMPA receptors, and stimulation of a nitric oxide/cGMP cascade may also be involved in this process.
小脑长期抑郁是平行纤维与浦肯野神经元突触在平行纤维和攀缘纤维共同激活时所诱导的一种持续性、输入特异性减弱。这种现象赋予浦肯野神经元强大的联合计算能力。最近的研究提供了强有力的证据，表明诱导长期抑郁需要两种机制，即通过电压门控通道的Ca2+内流和通过代谢型受体激活对蛋白激酶C的刺激。此外，另外两种机制，即通过AMPA受体的Na+内流和一氧化氮/cGMP级联反应的刺激也可能参与这一过程。
