Hillarby M C, McMahon M J, Grennan D M, Cooper R G, Clarkson R W, Davies E J, Sanders P A, Chattopadhyay C, Swinson D
University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford.
Br J Rheumatol. 1993 Sep;32(9):794-7. doi: 10.1093/rheumatology/32.9.794.
We have examined HLA-DR, DQA and DQB variants in 72 controls, 153 subjects with RA without extra-articular features and in subjects with the rheumatoid pulmonary complications of interstitial fibrosis (23) peripheral airways disease (13) and in 41 subjects with RA and bronchiectasis. Subjects with RA alone showed the expected association with HLA-DR4 (79%) but those with RA and co-existent pulmonary fibrosis were less likely to be DR4 positive (61%). No other HLA-DR variants were significantly increased in the different disease groups. HLA-DQB10501 which types serologically as DQw1 was increased in subjects with RA and peripheral airways disease as compared to rheumatoid subjects with normal lung function, but these differences were not statistically significant. DQB10601 was increased in subjects with bronchiectasis with or without RA (but only significantly so in RA-BR subjects) DQB10301, DQB10201 and DQA1*0501 frequencies were also increased in subjects with RA and bronchiectasis as compared to those with RA alone.
我们检测了72名对照者、153名无关节外表现的类风湿关节炎（RA）患者、患有间质性肺纤维化（23例）、外周气道疾病（13例）等类风湿肺部并发症的患者以及41例患有RA和支气管扩张症的患者的HLA-DR、DQA和DQB变体。仅患有RA的患者显示出与HLA-DR4的预期关联（79%），但患有RA并伴有肺纤维化的患者DR4阳性的可能性较小（61%）。在不同疾病组中，没有其他HLA-DR变体显著增加。与肺功能正常的类风湿患者相比，血清学类型为DQw1的HLA-DQB10501在患有RA和外周气道疾病的患者中有所增加，但这些差异无统计学意义。DQB10601在患有或不患有RA的支气管扩张症患者中增加（但仅在RA-支气管扩张症患者中显著增加）。与仅患有RA的患者相比，DQB10301、DQB10201和DQA1*0501的频率在患有RA和支气管扩张症的患者中也有所增加。
