Persson P, Gagnemo-Persson R, Håkanson R
Department of Pharmacology, University of Lund, Sweden.
Calcif Tissue Int. 1993 Jun;52(6):460-4. doi: 10.1007/BF00571337.
Young male rats (100 g body weight) were fed diets containing varying amounts of calcium. Body weight and bone development were studied together with various endocrine parameters, including blood levels of Ca2+, calcitonin, parathyroid hormone, vitamin D, and gastrin, and the enterochromaffin-like (ECL) cell-related parameters gastric mucosal histidine decarboxylase activity and histamine concentration. A diet containing 0.5% calcium resulted in optimum body weight gain and bone development. A lower calcium intake impaired body weight gain and bone development. The impairment was manifested in reduced bone calcium content whereas the size of the bones was unaffected. The net absorption of calcium seemed to be proportional to the calcium intake. A low calcium diet (0.03%) raised the circulating levels of 1,25(OH)2D and parathyroid hormone and lowered 25(OH)D3 and Ca2+, whereas a high calcium diet (5.46%) raised calcitonin, Ca2+, 25(OH)D3, and 1,25(OH)2D. In addition, the low calcium diet lowered the circulating gastrin concentration and the histidine decarboxylase activity and histamine content of the ECL cells in the gastric mucosa. A high calcium diet raised the circulating gastrin concentration, but the rise was not associated with an increase in the histidine decarboxylase activity and histamine content.
选用年轻雄性大鼠（体重100克），喂食含钙量不同的日粮。研究其体重、骨骼发育情况以及各种内分泌参数，包括血液中Ca2+、降钙素、甲状旁腺激素、维生素D和胃泌素的水平，以及与肠嗜铬样（ECL）细胞相关的参数，如胃黏膜组氨酸脱羧酶活性和组胺浓度。含钙0.5%的日粮能使体重增加和骨骼发育达到最佳状态。钙摄入量较低会损害体重增加和骨骼发育。这种损害表现为骨钙含量降低，而骨骼大小不受影响。钙的净吸收似乎与钙摄入量成正比。低钙日粮（0.03%）会使1,25(OH)2D和甲状旁腺激素的循环水平升高，同时降低25(OH)D3和Ca2+，而高钙日粮（5.46%）则会使降钙素、Ca2+、25(OH)D3和1,25(OH)2D升高。此外，低钙日粮会降低循环胃泌素浓度以及胃黏膜中ECL细胞的组氨酸脱羧酶活性和组胺含量。高钙日粮会使循环胃泌素浓度升高，但这种升高与组氨酸脱羧酶活性和组胺含量的增加无关。
