Russell J H, Wang R
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis 63110.
Eur J Immunol. 1993 Sep;23(9):2379-82. doi: 10.1002/eji.1830230951.
Antigen receptor-directed suicide plays an important role in the elimination of potentially autoaggressive immature T cells during thymic differentiation. Here we demonstrated evidence for a second pathway of receptor-directed suicide in mature T cells that is missing in a mutant strain (gld) of mice with an "autoimmune" lymphoproliferative syndrome. The defect is evident within the gld activated T cell and does not require the presence of an antigen-presenting cell for its expression. Receptor-driven suicide is intact in immature T cells of animals with this mutation. These results support the significance of receptor-directed suicide in the mature T cell compartment and suggest that the immune system may use three independent pathways for regulating programmed cell death in shaping and controlling the immune response.
抗原受体导向的自杀在胸腺分化过程中消除潜在的自身攻击性未成熟T细胞方面发挥着重要作用。在此，我们证明了成熟T细胞中存在受体导向自杀的第二条途径的证据，而在患有“自身免疫性”淋巴细胞增生综合征的小鼠突变株（gld）中该途径缺失。该缺陷在gld活化的T细胞中很明显，并且其表达不需要抗原呈递细胞的存在。受体驱动的自杀在具有这种突变的动物的未成熟T细胞中是完整的。这些结果支持了受体导向自杀在成熟T细胞区室中的重要性，并表明免疫系统可能使用三种独立的途径来调节程序性细胞死亡，以塑造和控制免疫反应。
